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KMID : 1161420170200090838
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Journal of Medicinal Food
2017 Volume.20 No. 9 p.838 ~ p.845
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BRM270, a Compound from Natural Plant Extracts, Inhibits Glioblastoma Stem Cell Properties and Glioblastoma Recurrence
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Jeon Hee-Young
Park Cheol-Gyu
Ham Seok-Won
Choi Sang-Hun
Lee Seon-Yong
Kim Jung-Yun
Seo Sun-Young
Jin Xiong
Kim Jun-Kyum
Eun Ki-Young
Kim Eun-Jung
Kim Hyung-Gee
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Abstract
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Glioblastoma multiforme (GBM) is one of the most aggressive and lethal human brain tumors, and the median survival of patients with GBM is only 14 months. Glioblastoma stem cells (GSCs) are regarded as a main cause of GBM recurrence, because of their self-renewal and drug resistance properties. Therefore, targeting GSCs is an important therapeutic strategy for GBM. In this study, we show the effects of BRM270, a compound from natural plant extracts, on GSCs in vitro and GBM recurrence in vivo. BRM270 induced apoptotic cell death and inhibited cell growth and “stemness” both in vitro and in vivo. Combining BRM270 treatment with concurrent chemoradiotherapy (CCRT) dramatically increased mice survival and tumor growth inhibition. Taken together, our results suggested that BRM270 synergizes with CCRT as a therapeutic agent to target GSCs.
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KEYWORD
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BRM270, concurrent chemoradiotherapy, glioblastoma multiforme, glioblastoma stem cells, natural plant extract
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